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ritlecitinib will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Ritlecitinib inhibits CYP3A4 substrates; coadministration will increase AUC and peak plasma concentration sensitive substrates, which may raise risk of adverse reactions.If coadministration of CYP3